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    The continuous replacement of neurons in the olfactory epithelium provides an advantageous model for investigating neuronal differentiation and maturation. The control of gene expression by chromatin modification and transcription factors, and neurite growth, protein transport, RNA processing, cholesterol biosynthesis, and apoptosis via death domain receptors, were overrepresented biological processes in immature OSNs. Ion transport ion channels , presynaptic functions, and cilia-specific processes were overrepresented in mature OSNs. Processes overrepresented among the genes expressed by all OSNs were protein and ion transport, ER overload response, protein catabolism, and the electron transport chain.
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    Deep sequencing of microRNA precursors reveals extensive 3′ end modification

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    Deep sequencing of microRNA precursors reveals extensive 3′ end modification

    We had some issues with the comment system acting up yesterday. While fixing it, I decided to create a new page for the Q and A since the old one had way too many comments on it and it was making the loading very slow. So we are starting from a fresh start with this new Q and A that looks identical to the old one, by the way. Hi Tom, Thanks for bringing up the headphone to attention. I saw it a while ago and thought it was very interesting. I know how the closed Philips headphone sounds, and while they are not in any way audiophile quality, I think they have good fundamentals think something like the HD Sennheiser. Anyway long story short I think I got distracted with work and other things and totally forgot about it.
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    Genomics of Mature and Immature Olfactory Sensory Neurons

    This has been demonstrated for the Let-7 family of miRNAs in embryonic cells. Additionally, nontemplated nucleotides have been found on mature miRNA species, though in most cases it is not known if nucleotide addition occurs at the precursor step or at the mature miRNA. To examine the diversity of nucleotide addition we have developed a high-throughput sequencing method specific for miRNA precursors. Here we report that nontemplated addition is a widespread phenomenon occurring in many miRNA families. As previously reported, Let-7 family members are oligo-uridylated in embryonic cells in a Lindependent manner.
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